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The coroner for Northern Ireland has called the rising number of deaths linked to fake versions of the anti-anxiety drug, Xanax, “an escalating crisis”. Joe McCrisken says he is signing off an alprazolam-related death nearly once a week. He says “most of the deaths” are caused by counterfeit versions of Xanax, the brand name for the drug alprazolam. “The deaths are a very tiny tip of what is a very huge iceberg,” he says. Xanax
The FDA has approved phentermine hydrochloride USP 8 mg, a low-dose medication for adults with obesity that can be taken up to three times daily, KVK Tech, Inc. announced in a press release. The new lower-dose phentermine (Lomaira) is intended to be used for weight reduction as an adjunct to diet and exercise in adults with an initial BMI of at least 30 kg/m² or at least 27 kg/m² with at least one weight-related comorbidity, such as
arcotic analgesics: Indications for NORCO: Acute pain severe enough to require opioid analgesic and for which alternative treatments are inadequate. Limitations of Use: Reserve for use in patients for whom alternative treatment options (eg, non-opioid analgesics) are ineffective, not tolerated, or would be otherwise inadequate. Adult: Use lowest effective dose for shortest duration. Individualize. 5mg/325mg: 1–2 tabs every 4–6hrs as needed; max 8 tabs/day. 7.5mg/325mg, 10mg/325mg: 1 tab every 4–6hrs as needed; max 6 tabs/day.
A label for 50 mg of Ultram (tramadol) tablets.Credit: National Institutes of Health. Tramadol is a prescription medication used to treat moderate to moderately severe pain. It is sold under the brand name Ultram in the United States, and as Ralivia, Dromodol and other names elsewhere. It is intended to work by changing the way the central nervous system responds to pain. Tramadol is effective on two fronts: About 20 percent of its painkilling effects
Daryl, who has had an opioid use disorder for more than a decade, prepares to inject Suboxone he bought on the street. He said it helped him remember what being normal felt like. (Seth Herald/WFYI) This story is part of a partnership that includes Side Effects Public Media, NPR and Kaiser Health News.This story can be republished for free (details). Months in prison didn’t rid Daryl of his addiction to opioids. “Before I left the parking lot of
An option for people with opioid-induced constipation Key points Provides equivalent analgesia to that of oxycodone controlled-release (CR) tablets Clinical data are largely from people with chronic musculoskeletal pain. The naloxone component reduces, but does not eliminate, opioid-induced constipation In key trials, the prevalence of constipation with oxycodone-with-naloxone CR compared with oxycodone CR was about 25% lower among people with a history of constipation, and 7% lower in an unselected group. Long-term effect on constipation